2D binary QSAR modeling of LPA3 receptor antagonism
نویسندگان
چکیده
منابع مشابه
Comparison of Different 2D and 3D-QSAR Methods on Activity Prediction of Histamine H3 Receptor Antagonists
Histamine H3 receptor subtype has been the target of several recent drug development programs. Quantitative structure-activity relationship (QSAR) methods are used to predict the pharmaceutically relevant properties of drug candidates whenever it is applicable. The aim of this study was to compare the predictive powers of three different QSAR techniques, namely, multiple linear regression ...
متن کاملComparison of Different 2D and 3D-QSAR Methods on Activity Prediction of Histamine H3 Receptor Antagonists
Histamine H3 receptor subtype has been the target of several recent drug development programs. Quantitative structure-activity relationship (QSAR) methods are used to predict the pharmaceutically relevant properties of drug candidates whenever it is applicable. The aim of this study was to compare the predictive powers of three different QSAR techniques, namely, multiple linear regression ...
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متن کاملcomparison of different 2d and 3d-qsar methods on activity prediction of histamine h3 receptor antagonists
histamine h3 receptor subtype has been the target of several recent drug development programs. quantitative structure-activity relationship (qsar) methods are used to predict the pharmaceutically relevant properties of drug candidates whenever it is applicable. the aim of this study was to compare the predictive powers of three different qsar techniques, namely, multiple linear regression (mlr)...
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Introduction: Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor derivatives play an important role in the treatment of cancer. We aim to construct 2D-QSAR models using various chemometrics using 4-anilinoquinazoline-containing EGFR TKIs. In addition, the binding profile of these compounds was evaluated using a docking study. Materials and Methods: In this study, 122 compounds of...
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ژورنال
عنوان ژورنال: Journal of Molecular Graphics and Modelling
سال: 2010
ISSN: 1093-3263
DOI: 10.1016/j.jmgm.2010.03.002